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Primaquine Warnings and Precautions

Specific Precautions and Warnings for Primaquine

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Primaquine may cause certain kinds of anemia or other dangerous blood cell problems. Some people may have an increased risk for these problems, including people who have had such a reaction in the past, are taking higher primaquine doses than normal, or have a genetic condition known as glucose-6-phosphate dehydrogenase (G6PD) deficiency. If you are at risk for these problems, your healthcare provider will monitor you closely. You may need regular blood tests while taking primaquine.
In addition, you should contact your healthcare provider immediately if you develop any symptoms of anemia or other blood cell problems, such as:
    • Dark urine
    • Fatigue or extreme weakness or tiredness
    • Pale skin
    • Rapid heartbeat
    • Shortness of breath
    • Yellowing of the whites of the eyes or skin (jaundice)
    • High fever, chills, aches, and pains, which may be signs of an infection.
 
  • Primaquine may interact with a number of other medications (see Primaquine Drug Interactions for more information).
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  • Primaquine is normally considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are unknown (see Primaquine and Pregnancy).
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  • It is unknown if primaquine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Primaquine and Breastfeeding).
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Primaquine Medication Information

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