Primaquine Drug Interactions
Primaquine may increase the level of cyclosporine in your blood, which can be quite dangerous. If you take these two medications together, your healthcare provider may need to monitor your cyclosporine levels and adjust your cyclosporine dosage if necessary.
CYP 3A4 Inducer Medications
The body breaks down primaquine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining primaquine with one of these CYP 3A4 inducers may decrease the level of primaquine in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure primaquine is working if you take it with a CYP 3A4 inducer.
Taking primaquine with dapsone may increase the risk for serious blood reactions. This risk is probably highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M. If you have one of these conditions, you should discuss this with your healthcare provider before starting primaquine treatment. If you do take these medications together, your healthcare provider will need to closely monitor you for blood reactions.
Primaquine may increase the level of digoxin in the body, which can be potentially dangerous. If you take digoxin and need primaquine treatment, your healthcare provider may need to monitor your digoxin level with a simple blood test.
Taking primaquine with flutamide may increase the amount of flutamide in the body, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medications together.