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Safety of Malarone

Malarone® (atovaquone/proguanil) is a malaria drug that is available by prescription only. To help ensure an effective and safe course of treatment, Malarone should be taken exactly as prescribed. Most people are able to take this product without any problems, but it is not without risks.
For example, Malarone increases your risk of life-threatening skin rashes called Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). It can also increase liver enzymes, especially at the beginning of treatment. In rare cases, this can lead to liver failure, hepatitis, and other liver problems. Contact your healthcare provider immediately if you develop any of the following signs of liver problems:
  • Dark urine
  • Loss of appetite
  • Pain in the upper part of the stomach
  • Yellowing of the whites of the eyes or skin (jaundice).
Also, keep in mind that you can still get malaria while taking this product. Malarone reduces the risk, but it's still important to take preventive measures to avoid contact with mosquitoes, such as using bed nets and wearing protective clothing.
(Click Malarone Warnings and Precautions for more safety information, including a list of people who may need to avoid the drug entirely.)
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