Malaria Home > Malarone

If you have an uncomplicated case of malaria, your healthcare provider may prescribe Malarone, a drug that contains two different types of antimalarial medication. This product can also be used to prevent malaria. It comes in the form of a tablet and is generally taken once a day. Possible side effects include stomach pain, vomiting, and headache.

What Is Malarone?

Malarone® (atovaquone/proguanil) is a prescription medication licensed to prevent or treat malaria. It is a combination of two antimalarial medicines: atovaquone and proguanil.
(Click Malarone Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Malarone is made by GlaxoSmithKline.

How Does Malarone Work?

Malarone belongs to the antimalarial class of medications. Malaria is a blood infection caused by tiny parasites called Plasmodium. Plasmodium are usually introduced into the bloodstream by the bite of an infected mosquito. Once in the bloodstream, these parasites start to reproduce.
Malarone prevents Plasmodium parasites from copying nucleic acid, an essential step in their reproduction. The two components of Malarone do this in slightly different ways, allowing them to work well in combination to prevent Plasmodium parasites from reproducing in the bloodstream.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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