If you have an uncomplicated case of malaria, your healthcare provider may prescribe Malarone, a drug that contains two different types of antimalarial medication. This product can also be used to prevent malaria. It comes in the form of a tablet and is generally taken once a day. Possible side effects include stomach pain, vomiting, and headache.
What Is Malarone?
Malarone® (atovaquone/proguanil) is a prescription medication licensed to prevent or treat malaria. It is a combination of two antimalarial medicines: atovaquone and proguanil.
Malarone belongs to the antimalarial class of medications. Malaria is a blood infection caused by tiny parasites called Plasmodium. Plasmodium are usually introduced into the bloodstream by the bite of an infected mosquito. Once in the bloodstream, these parasites start to reproduce.
Malarone prevents Plasmodium parasites from copying nucleic acid, an essential step in their reproduction. The two components of Malarone do this in slightly different ways, allowing them to work well in combination to prevent Plasmodium parasites from reproducing in the bloodstream.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Malarone [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2009 September.
Micromedex Healthcare Series [Internet database]. Greenwood Village, CO: Thomson Reuters (Healthcare), Inc. Updated periodically. Accessed October 4, 2010.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 28, 2011.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed October 5, 2010.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed October 5, 2010.
Centers for Disease Control and Prevention. CDC Health Information for International Travel 2010. Atlanta: U.S. Department of Health and Human Services, Public Health Service, 2009.
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