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Malarone Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Malarone is combined with any of the drugs listed above.
Taking Malarone with artemether-lumefantrine, another antimalarial medication, may make the side effects of Malarone or artemether-lumefantrine more pronounced. Sometimes, antimalarial medications are used together to treat malaria -- however, this should only be done under the supervision of a healthcare provider.
Taking Malarone with dapsone may increase your risk of serious blood reactions. This risk is highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M.
If you have one of these conditions, you should discuss this drug interaction with your healthcare provider. If you do take these medications together, your healthcare provider may choose to closely monitor you for blood reactions.
Malarone may increase the levels of etoposide in your body, increasing your risk for adverse reactions. Your healthcare provider may choose to separate your doses of Malarone and etoposide by one to two days to help reduce the risk of this drug interaction.
Malarone may reduce the levels of indinavir in your body, potentially making it less effective. If you take these medications together, your healthcare provider may choose to monitor you more closely to make sure you are responding to indinavir.
Metoclopramide may reduce the levels of Malarone in your body, potentially making it less effective. Talk to your healthcare provider about the best medication to use if you need something for nausea and vomiting while taking Malarone. Metoclopramide should only be used if no other options are available.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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