Malaria Home > Coartem Drug Interactions

Many products can cause negative interactions with Coartem, including grapefruit juice, birth control pills, and certain beta blockers. Some of these reactions can alter the amount of the medications in the blood, possibly making them less effective or increasing your risk for side effects. Before starting treatment with Coartem, tell your healthcare provider about any other medications, herbs, or supplements you are taking.

An Overview of Interactions With Coartem

Coartem® (artemether/lumefantrine) is a prescription medication licensed to treat malaria infections. This product may potentially interact with many other medications.
Some of the medications that may lead to Coartem drug interactions include but are not limited to:
  • Anti-retroviral HIV medicines, such as:
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medications, such as:
  • CYP 3A4 inhibitor medications, such as:
    • Amprenavir (Agenerase®)
    • Atazanavir (Reyataz®)
    • Clarithromycin (Biaxin®)
    • Conivaptan (Vaprisol®)
    • Darunavir (Prezista®)
    • Delavirdine (Rescriptor®)
    • Erythromycin
    • Fosamprenavir (Lexiva®)
    • Imatinib (Gleevec®)
    • Indinavir (Crixivan®)
    • Isoniazid
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Lopinavir and ritonavir (Kaletra®)
    • Miconazole
    • Nefazodone (Serzone®)
    • Nelfinavir (Viracept®)
    • Nicardipine (Cardene®)
    • Posaconazole (Noxafil®)
    • Quinidine
    • Ritonavir (Norvir®)
    • Saquinavir (Fortovase®, Invirase®)
    • Telithromycin (Ketek®)
    • Voriconazole (VFEND®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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