Most people get malaria from the bite of an infected female Anophelesmosquito. Through the bite, a microscopic parasite called Plasmodium enters the body and causes infection, with malaria symptoms typically appearing 10 to 30 days after a person becomes infected.
Chloroquine phosphate (Aralen®) works by killing the Plasmodium parasites that cause the infection. How does it kill the parasites? Chloroquine's mode of action is not entirely clear -- however, it is possible that the drug stops the parasites from reproducing by interfering with their DNA.
(Click Chloroquine to learn more about the drug's mode of action. This article also tells you about possible side effects, safety warnings, dosing guidelines, and more.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Aralen [package insert]. Bridgewater, NJ: sanofi-aventis, U.S. LLC;2008 September.
Micromedex Healthcare Series [Internet database]. Greenwood Village, CO: Thomson Reuters (Healthcare), Inc. Updated periodically. Accessed October 12, 2010.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 12, 2010.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed October 13, 2010.
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