Malaria Home > Drug Interactions With Chloroquine
Chloroquine may increase the level of digoxin in the body, which can be dangerous. If you take digoxin and need chloroquine treatment, your healthcare provider may need to monitor your digoxin level with a simple blood test.
Taking chloroquine with fesoterodine may increase the amount of fesoterodine in the body, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medications together.
In general, chloroquine should not be combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm), due to the risk of a life-threatening arrhythmia. Talk to your healthcare provider before taking chloroquine with a QT-prolonging medication.
Taking chloroquine with other antimalarial medications may lead to serious reactions, including the risk for seizures or QT prolongation, a dangerous type of arrhythmia. You should talk to your healthcare provider before taking chloroquine with other antimalarial medications.
Chloroquine may increase phenothiazine levels in the body, increasing the risk for side effects. If you take these medications together, your healthcare provider may need to monitor you more closely for side effects of phenothiazine, such as extreme sedation.
Chloroquine may decrease the effectiveness of the rabies vaccine. If you need a rabies vaccine while taking chloroquine, your healthcare provider will need to monitor your response to the vaccine to make sure it worked for you.
The body transforms tamoxifen into another substance (a tamoxifen metabolite) that is more active than tamoxifen itself. Chloroquine may decrease the amount of tamoxifen metabolite formed in the body, potentially making tamoxifen less effective. Talk to your healthcare provider before taking these medications together.