Malaria Home > Drug Interactions With Chloroquine

Cyclosporine
Chloroquine may increase the level of cyclosporine in your blood, which can be quite dangerous. If you take these two medications together, your healthcare provider may need to monitor your cyclosporine levels, and adjust your dosage if necessary.
 
CYP 2D6 Inhibitor Medications
The body breaks down chloroquine using enzymes in the liver known as CYP 2D6 enzymes. Medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Combining chloroquine with one of these CYP 2D6 inhibitors may increase the level of chloroquine in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you take these medications together.
 
CYP 3A4 Inducer Medications
The body breaks down chloroquine using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining chloroquine with one of these CYP 3A4 inducers may decrease the level of chloroquine in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure chloroquine is working if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The body breaks down chloroquine using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining chloroquine with one of these CYP 3A4 inhibitors may increase the level of chloroquine in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you take these drugs together.
 
Dapsone
Taking chloroquine with dapsone may increase the risk for serious blood reactions. This risk is probably highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M.
 
If you have one of these conditions, you should discuss this drug interaction with your healthcare provider before starting chloroquine treatment. If you do take these medications together, your healthcare provider will need to closely monitor you for blood reactions.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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