Malaria Home > Chloroquine Dosage

What Is the Chloroquine Dosage for Treating Amebiasis?

The usual dose for treating extraintestinal amebiasis is chloroquine 1000 mg once a day for two days, then 500 mg once a day for two to three weeks.

General Information on Taking Chloroquine

Some considerations to keep in mind during treatment with chloroquine include the following:
  • Chloroquine comes in tablet form. It is usually taken once a week to prevent malaria, starting two weeks before the anticipated exposure and continuing for eight weeks after leaving the malaria area. To treat malaria, the drug is taken twice a day for one day and then once a day for two more days. When used for amebiasis, it is taken once a day.
  • This medication should be taken with food to prevent stomach upset.
  • Sometimes the strength of this medication is stated in different terms. For example, 500 mg of chloroquine phosphate is equivalent to 300 mg of chloroquine (without the phosphate). All the dosages in this article were stated in terms of chloroquine phosphate.
  • Although this medication can be crushed, it is extremely bitter tasting. Talk to your doctor or pharmacist about possible solutions to this problem if chloroquine is being used in someone who has difficulty swallowing the tablets, such as a child. Sometimes the crushed medication can be mixed with something sweet, such as chocolate syrup or jelly.


  • Be sure to take each dose of chloroquine on the same day of the week (if you are taking it weekly) or at the same time each day (if you are taking it daily) to keep an even level in your bloodstream.
  • It is important to use protective clothing, bed nets, and insect repellents to protect yourself from being bitten by mosquitoes in a malaria area. Chloroquine alone may not prevent infection.
  • Make sure you continue to take this medication for the full treatment course, even if you start to feel better. Not finishing the medicine may cause the prevention or treatment to fail.
  • No medication is completely effective at treating or preventing malaria. Contact your healthcare provider if you get flu-like symptoms, such as fever, chills, and muscle aches and pains while in a malaria area, after returning from the area, or after finishing chloroquine treatment.
  • For chloroquine to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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