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Lariam Drug Interactions

QT-Prolonging Medications
In general, Lariam should not be combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm), due to the risk of a life-threatening arrhythmia. Talk to your healthcare provider before taking Lariam with another QT-prolonging medication.
 
Other Antimalarials
Taking Lariam with other antimalarial medications may lead to serious reactions, including the risk for seizures or QT prolongation, a dangerous type of arrhythmia. Halofantrine (another antimalarial) should not be used within 15 weeks of the last Lariam dose. When antimalarial medications are used together to treat malaria, it must be done with a healthcare provider's approval and supervision.
 
Phenothiazine Medications
Lariam may increase phenothiazine levels in the body, increasing the risk for side effects. This interaction has only been reported in people taking other antimalarial medications. However, because of the similarities between Lariam and these other medications, it may be a good idea to watch for possible phenothiazine side effects, such as extreme sedation, if you take a phenothiazine with Lariam.
 
Silodosin
Lariam may increase the level of silodosin in your body, increasing your risk for side effects. If you take these medications together, your healthcare provider may choose to monitor you more closely. Talk to your healthcare provider before taking Lariam with silodosin.
 
Topotecan
Taking Lariam with topotecan may increase the amount of topotecan in your body, increasing your risk for potentially serious side effects. If you take these medications together, your healthcare provider may need to monitor you more closely for topotecan side effects.
 
Typhoid Vaccine
Lariam may decrease the effectiveness of certain types of typhoid vaccine. Only the live typhoid vaccine, taken by mouth, is thought to interact with Lariam. Therefore, it is recommended that live typhoid vaccination be given either three days before or one day after Lariam treatment.

Lariam Medication Information

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