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Lariam Drug Interactions

Lariam Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Lariam is combined with any of the drugs listed above.
 
Anticonvulsants
Lariam may decrease anticonvulsant levels in your body, potentially making the anticonvulsant less effective and increasing your risk for seizures. If you take these medications together, your healthcare may choose to monitor your anticonvulsant blood levels.
 
Colchicine
Taking Lariam with colchicine may increase the amount of colchicine in your body, increasing your risk for dangerous side effects. If you take these medications together, your healthcare provider may need to monitor you more closely for colchicine side effects. You may need a lower colchicine dose.
 
CYP 3A4 Inducer Medications
The body breaks down Lariam using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining Lariam with one of these CYP 3A4 inducers may decrease the level of Lariam in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure Lariam is working if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The body breaks down Lariam using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Lariam with one of these CYP 3A4 inhibitors may increase the level of Lariam in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you take Lariam with a CYP 3A4 inhibitor.
 
Dapsone
Taking Lariam with dapsone may increase the risk for serious blood reactions. This risk is probably highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M. If you have one of these conditions, you should discuss this interaction with your healthcare provider before starting Lariam treatment. If you do take these medications together, your healthcare provider will need to closely monitor you for blood reactions.

Lariam Medication Information

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