For adults, the recommended dose for malaria treatment is 800 mg for the first dose, followed by 400 mg for the second dose six to eight hours later, then followed by 400 mg per day for the next two days. Alternatively, a single 800 mg dose may also be effective.
For children and infants, the recommended dose is 10 mg per kg of body weight (about 4.5 mg per pound) for the first dose, followed by 5 mg per kg (about 2.3 mg per pound) for the second dose six to eight hours later, then followed by 5 mg per kg (about 2.3 mg per pound) once daily for the next two days.
For certain types of malaria, hydroxychloroquine may need to be combined with another anti-malarial drug in order to be effective.
For treating lupus in adults, the recommended starting hydroxychloroquine dosage is 400 mg once or twice a day. After a while, your healthcare provider may recommend a lower dosage (such as 200 mg once daily). The higher the long-term dosage, the more likely that serious hydroxychloroquine side effects (especially eye damage) may occur.
The recommended starting hydroxychloroquine dose for rheumatoid arthritis treatment is 400 to 600 mg daily. In some people, the starting dose may need to be temporarily reduced (for a week or so) if bothersome side effects occur. After a good response is obtained (usually four to six weeks), your healthcare provider will recommend that your dose be reduced to 200 to 400 mg daily. The higher the long-term dosage, the more likely that serious side effect (especially eye damage) may occur.