Coartem Drug Interactions
Taking Coartem with dapsone can increase the risk for serious blood reactions. This risk is probably highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M. If you have one of these conditions, you should discuss this interaction with your healthcare provider before starting Coartem treatment. If you do take these medications together, your healthcare provider may need to closely monitor you for blood reactions.
Grapefruit juice may increase the amount of Coartem in your blood, potentially increasing your risk for serious side effects. You should avoid drinking grapefruit juice while you are taking Coartem.
In general, Coartem should not be combined with any other medication that can cause QT prolongation (a certain change in the heart rhythm), due to the risk of a life-threatening arrhythmia. Talk to your healthcare provider before taking Coartem with another QT-prolonging medication.
Taking Coartem with other antimalarial medications may lead to serious reactions, such as QT prolongation (a dangerous type of arrhythmia). Some antimalarial medications should not be given for at least a month after Coartem treatment. Coartem should only be given with other antimalarial medicines when there are no other treatment options, and only when managed by a healthcare provider.
Coartem may increase phenothiazine levels in the blood, increasing the risk for side effects. This interaction has only been reported in people taking other antimalarial medications. However, because of the similarities between Coartem and these other medications, it may be a good idea to watch for possible phenothiazine side effects, such as extreme sedation, if you take a phenothiazine with Coartem.