Coartem Drug Interactions
Coartem Drug Interactions ExplainedThe following sections explain in detail the potentially negative reactions that can occur when Coartem is combined with any of the drugs listed above.
Anti-Retroviral Medicines (HIV Medications)
Taking Coartem with an anti-retroviral medication may decrease the level of the anti-retroviral in your body, making it less effective. Taking these medicines together may also either increase or decrease the level of Coartem in your body. Because of the potential for these interactions, your healthcare provider may monitor you more closely if you take Coartem with an anti-retroviral.
Birth Control Pills and Patches
Taking Coartem with birth control pills can make the birth control pills less effective, increasing the possibility that you will become pregnant. You also may experience bleeding between menstrual cycles. Talk to your healthcare provider about other methods for birth control if you are taking Coartem.
Certain Beta Blockers
Coartem may increase the level of certain beta blocker medications in your body, potentially lowering your blood pressure too much. If your blood pressure becomes too low, you may feel dizzy, lightheaded, or faint. If you are taking a beta blocker that may interfere with Coartem, your healthcare provider may choose to monitor your blood pressure more closely during treatment.
Codeine Pain Medications
Coartem can make codeine less effective at controlling pain. If you are taking codeine and Coartem together, your healthcare provider will monitor your response to codeine. Tell your healthcare provider if your pain is not adequately controlled, as you may need a different pain medication.
Strong 3A4 Inducers
The body breaks down Coartem using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining Coartem with a CYP 3A4 inducer may decrease the level of Coartem in your body, making it less effective.
Different medications induce CYP 3A4 to different extents. Strong CYP 3A4 inducers should not be combined with Coartem, due to the strong likelihood that they will make Coartem significantly less effective.
CYP 3A4 Inhibitor Medications
The body breaks down Coartem using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Coartem with one of these CYP 3A4 inhibitors may increase the level of Coartem in your body, increasing your risk for serious side effects. Your healthcare provider may monitor you more closely for side effects if you take Coartem with a CYP 3A4 inhibitor.